In:
The EMBO Journal, EMBO, Vol. 42, No. 17 ( 2023-09-04)
Abstract:
image The cullin‐RING E3 ligase family CRL4 is based on two structurally similar scaffold subunits, CUL4A and CUL4B. Here, the unique N‐terminal extension in the CUL4B paralogue is found to be heavily phosphorylated in mitosis, which promotes the recruitment of a specific set of substrate receptors (DCAFs). The N-terminus of CUL4B is phosphorylated during mitosis, and efficient phosphorylation is required for proper progression through mitosis. CRL4B, but not CRL4A, recruits phospho‐specific DCAFs such as LIS1 and WDR1, which are involved in cytoskeleton regulation. CUL4B is required to develop stable ventricular structures in human forebrain organoids. A CUL4B patient mutation (P50L) alters mitotic phosphorylation and leads to X‐linked intellectual disability (XLID).
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022112847
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
