In:
The EMBO Journal, EMBO, Vol. 42, No. 15 ( 2023-08)
Kurzfassung:
image The presence and functions of N6‐methylation of deoxyadenosine (6mA) in animal genomes are disputed. This study shows that N6‐methyladenosine (m6A)‐decorated maternal RNA is the source of 6mA in cnidarian embryonic genomes, from which it has to be removed for initiation of zygotic transcription. Rapid degradation of m6A‐marked maternal RNAs generates a nucleotide pool containing m6A. After NTP‐to‐dNTP conversion by a ribonucleotide reductase, 6mA is randomly incorporated into the embryonic genome. Genomic 6mA interferes with embryonic transcription. Removal of 6mA by the 6mA dioxygenase Alkbh1 facilitates timely zygotic genome activation.
Materialart:
Online-Ressource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022112934
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2023
ZDB Id:
1467419-1
ZDB Id:
586044-1
SSG:
12
