In:
The EMBO Journal, EMBO, Vol. 42, No. 16 ( 2023-08-15)
Abstract:
image Mitochondrial damage, which can occur during viral infection, results in the release of damage‐associated molecular patterns (DAMPs) and can drive innate antiviral immunity via multiple pathways. Here, inhibition of NRF1‐mediated mitochondrial biogenesis was found to aggravate virus‐induced mitochondrial damage and promote innate antiviral immunity by enhancing mitochondrial DAMPs release. RNA and DNA viral infection activates NRF1‐mediated mitochondrial biogenesis in mouse and human immune cells. Deficiency of NRF1‐mediated mitochondrial biogenesis enhanced innate antiviral response in mice. Mitochondrial DAMPs, promoted by NRF1 deficiency, contribute to innate antiviral immunity. TBK1‐induced NRF1 phosphorylation is physiologically important to host antiviral response.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022113258
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12