In:
The EMBO Journal, EMBO, Vol. 42, No. 19 ( 2023-10-04)
Abstract:
image Red blood cells (RBCs) have circadian rhythms, but their physiological functional is poorly understood. A novel reporter system reveals oscillations of haemoglobin (Hb) oxidation status in vitro and in vivo , which contribute to the rhythmic regulation of body temperature through nitric oxide (NO) signalling. A novel biochemical assay reports Hb oxidation status. Hb oxidation (metHb) is rhythmic in mouse and human RBCs cultured in vitro . Daily variation in redox status is observed in humans in vivo , with highest metHb levels during the rest phase. Increased metHb in RBCs during the rest phase correlates with reduced core body temperature and an increase in peripheral vasodilation due to NO signalling. Manipulation of in vivo metHb status with sodium nitrite causes core body cooling.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2023114164
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12