In:
EMBO reports, EMBO, Vol. 17, No. 5 ( 2016-05), p. 753-768
Abstract:
image Retrotransposons can be activated under cellular stress conditions or at specific developmental stages. This study reveals a new mechanism of dynamic retrotransposon regulation by alternative transcription start site (TSS) selection. Fun30 chromatin remodelers maintain a critical nucleosome in LTR elements leading to the usage of a downstream TSS and the production of RNA incapable of reverse transcription and retrotransposition. In stressed cells, or in Fun30 mutants, the LTR nucleosome occupancy is reduced and the TSS shifts to allow for productive transcription and retrotransposition.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201541866
Language:
English
Publisher:
EMBO
Publication Date:
2016
detail.hit.zdb_id:
2025376-X
SSG:
12