In:
EMBO reports, EMBO, Vol. 18, No. 4 ( 2017-04), p. 619-631
Abstract:
image Increasing evidence indicates that the histone methyltransferase Ezh2 also modifies non‐histone substrates in a chromatin‐independent fashion. This study shows that Ezh2 controls immune homeostasis through such a non‐canonical mechanism by directly methylating the transcription factor PLZF . Loss of Ezh2 leads to the accumulation of PLZF high NKT cells, whereas the depletion of Eed and Suz12 blocks NKT cell development. PLZF in the expanded Ezh2‐depleted NKT cell population shows increased protein stability. Ezh2‐dependent methylation of PLZF creates a “methyl degron”, which promotes the ubiquitinylation and degradation of PLZF . Ezh2‐deficient PLZF high NKT cells perturb the homeostasis of T cells and B cells.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201643237
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2025376-X
SSG:
12
