In:
EMBO reports, EMBO, Vol. 21, No. 12 ( 2020-12-03)
Abstract:
image Hepatocyte ploidy is controlled by the PIDDosome and its loss causes increased hepatocyte ploidy, which protects mice from developing liver cancer. High tumor cell density, a surrogate of low ploidy, predicts poor recurrence free survival in HCC patients. The PIDDosome promotes DEN‐induced liver cancer in mice. Liver cancer arises preferentially from hepatocytes with low ploidy. Low tumor ploidy predicts poor recurrence‐free survival in HCC patients.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202050893
Language:
English
Publisher:
EMBO
Publication Date:
2020
detail.hit.zdb_id:
2025376-X
SSG:
12