In:
EMBO reports, EMBO, Vol. 23, No. 10 ( 2022-10-06)
Abstract:
image The functional importance of the SARS‐CoV‐2 spike N‐terminal domain is poorly understood. This study demonstrates that length variation in flexible loops within the NTD can modulate spike activity to optimise SARS‐CoV‐2 entry. SARS‐CoV‐2 spike NTD loops are a hotspot of diversity in emergent variants and sarbecoviruses in general. The NTD determines virus entry efficiency by Alpha and Omicron variants, and by Pangolin coronavirus. NTD loops may provide a mechanism for evolutionary fine tuning of spike activity.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202154322
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
2025376-X
SSG:
12