In:
EMBO reports, EMBO, Vol. 24, No. 3 ( 2023-03-06)
Kurzfassung:
image T cell‐dependent bispecific antibodies induce adverse systemic changes in addition to tumor killing. This study shows how different vascular beds respond to cancer immunotherapy, suggesting that reducing leukocyte‐endothelial interactions may limit the accumulation of T cells, thereby alleviating off‐tumor adverse responses. An in‐depth characterization of acute systemic responses to T cell‐dependent bispecific antibodies is presented. Immunological and vascular responses in the liver are observed that are more striking than the tumor responses. Liver response shows a vascular‐subtype‐dependent pattern. Transcriptional programs and candidate factors are uncovered that could account for the undesirable response.
Materialart:
Online-Ressource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255532
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2023
ZDB Id:
2025376-X
SSG:
12