In:
EMBO reports, EMBO
Kurzfassung:
image The transcriptional regulator Prox1 undergoes a fasting‐sensitive SUMOylation switch. Genetic ablation of Prox1 SUMOylation leads to alterations in lipoprotein cholesterol metabolism, establishing SUMOylation as a nutrient‐sensitive metabolic checkpoint. Transcription factor Prox1 is highly SUMOylated in the liver Fasting leads to rapid Prox1 de‐SUMOylation High‐fat diet feeding in mice ablates fasting sensitivity of Prox1 SUMOylation Genetic ablation of Prox1 SUMOylation alters lipoprotein cholesterol levels and controls bile acid synthesizing pathways in liver
Materialart:
Online-Ressource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255981
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2023
ZDB Id:
2025376-X
SSG:
12
