In:
EMBO reports, EMBO, Vol. 24, No. 4 ( 2023-04-05)
Abstract:
image Pericyte stem cells (PeSCs) represent a newly identified cell population that shares pericyte, stromal and stemness features and drives tumoral growth in pancreatic cancer. This study reports on the role of these cells within the tumor microenvironment. PeSCs are barely detectable in the pancreas under steady‐state conditions. PeSC are present in the neoplastic microenvironment in pancreatic cancer both in humans and mice. Co‐injection of PeSCs and tumor epithelial cells increases the differentiation of Ly6G + myeloid‐derived suppressor cells. PeSCs instruct immunosuppressive myeloid cell responses to bypass PD‐1 targeting.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202256524
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12