In:
EMBO reports, EMBO, Vol. 24, No. 12 ( 2023-12-06)
Abstract:
image Mass spectrometry‐based proximity labeling proteomics identifies regulators of PCP signaling in the Drosophila wing. Among those, the catalytic subunit of Protein Phosphatase1, Pp1‐87B, regulates core protein polarization. Mass spectrometry‐based proximity labeling proteomics was used to identify regulators of PCP signaling in the Drosophila wing. A secondary RNAi screen confirmed 95 proteins whose knockdown perturbs PCP signaling. Of those, the catalytic subunit of protein phosphatase1, Pp1‐87B, regulates core PCP protein polarization. Pp1‐87B modulates Van Gogh subcellular localization and directly or indirectly regulates its dephosphorylation in vivo .
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202356997
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12