In:
EMBO reports, EMBO
Abstract:
image In the human malaria parasite Plasmodium falciparum , the cohesin subunit SMC3 plays a role in stage‐specific gene repression that is distinct from heterochromatin‐mediated repression of genes involved in antigenic variation and gametocytogenesis. SMC3 knockdown results in the aberrant upregulation of genes involved in egress from and invasion into the human red blood cell at times when they are normally repressed. SMC3 binding to the promoters of these genes shows an inverse relationship with their transcriptional activity and chromatin accessibility.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202357090
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12