In:
EMBO reports, EMBO, Vol. 24, No. 12 ( 2023-12-06)
Abstract:
image Combining genetic lineage tracing and label retention experiments, this study shows that every‐other‐day intermittent fasting does not affect adult neural stem cell behaviour and, despite previous encouraging data, is not a reliable strategy to promote adult hippocampal neurogenesis in mice. Night‐time every‐other‐day intermittent fasting elicits a systemic fasting response in mice while preserving circadian activity. Intermittent fasting has no effect on the proliferation or maintenance of adult neural stem cells in the dentate gyrus. Irrespective of the mouse strain, sex, labelling method, diet length, or refeeding protocol evaluated in this work, intermittent fasting did not promote adult hippocampal neurogenesis.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202357268
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12