In:
EMBO reports, EMBO, Vol. 24, No. 12 ( 2023-12-06)
Abstract:
image T‐cell specific Rip1 KO mice show signs of accelerated aging‐like phenotypes, along with premature death. Blocking apoptosis by co‐deleting Fadd in Rip1 tKO mice significantly rescues aging‐like phenotypes and prolongs shortened lifespan. Rip1 tKO mice show similar age‐related T cell changes and exhibit signs of accelerated aging and a shorter lifespan. Rip1 ‐deficient T cells undergo excessive apoptosis, promoting chronic inflammation. Blocking necroptosis has little effect on the multimorbidity and premature aging seen in Rip1 tKO mice. Blocking T cell apoptosis by co‐deleting Fadd rescues premature aging and multimorbidity in Rip1 tKO mice.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202357925
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2025376-X
SSG:
12