In:
EMBO Molecular Medicine, EMBO, Vol. 6, No. 12 ( 2014-12), p. 1525-1541
Abstract:
image New highly specific inhibitors of HUWE 1 have been identified that can inhibit MYC function in a tumour cell‐specific manner, by preventing the HUWE 1‐mediated block of a repressive complex of MYC with MIZ 1 on MYC ‐activated target genes. HUWE1 is essential for growth of colorectal tumors in vivo and is globally required for expression of MYC target genes. Small‐molecule inhibitors of HUWE1 inhibit expression of MYC target genes in a tumor‐cell specific manner. Inhibition of HUWE1 stabilizes MIZ1 and induces global accumulation of MIZ1 on MYC‐bound target genes. Accumulation of MIZ1 is required for repression of ribosomal protein genes upon HUWE1 inhibition.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201403927
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
2485479-7