In:
EMBO Molecular Medicine, EMBO, Vol. 7, No. 3 ( 2015-03), p. 227-239
Abstract:
image Whole‐genome sequencing and further data analysis allowed for a comprehensive understanding of the emergence and spread of two highly virulent clones of drug‐resistant Klebsiella pneumonia bloodstream infections from one hospital in Kathmandu, Nepal. MDR Klebsiella pneumoniae (Kp) can cause serious hospital outbreaks and can be associated with high mortality in hospitals in developing countries. Whole‐genome sequencing (WGS) of Kp bloodstream infections was used to study localized transmission and genetic adaptation during a hospital outbreak in Nepal. Genetic material specific to outbreak lineages permitted a retrospective temporal reconstruction of two Kp outbreak lineages across the hospital. The added benefit of Kp WGS in this study was to dissect these outbreaks with extremely fine detail. Genetic characterization of Kp causing bloodstream infections in hospitals in developing countries should be performed routinely to identify and isolate outbreaks early.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201404767
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
2485479-7