In:
EMBO Molecular Medicine, EMBO, Vol. 9, No. 7 ( 2017-07), p. 918-932
Abstract:
image Molecular tracking of single tumor initiating cells ( TIC ) of pancreatic ductal adenocarcinoma ( PDAC ) xenografts in vivo reveals the functional and phenotypic plasticity of transiently active TIC producing temporally restricted tumor cell bursts. PDAC TIC are functionally and phenotypically plastic. Transiently active PDAC TIC produce tumor cells in a succession of temporally restricted bursts. Long‐term progression of pancreatic cancer is driven by functional plasticity.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201607354
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2485479-7