In:
Molecular Systems Biology, EMBO, Vol. 18, No. 4 ( 2022-04)
Abstract:
image Asymptomatic Plasmodium falciparum malaria infection supports protective humoral responses, but it also features an immunosuppressive transcriptional signature with upregulation of pathways involved in the inhibition of T‐cell function. Asymptomatic malaria is thought to be beneficial for maintaining clinical immunity and remains untreated. Despite supporting protective humoral immune responses, asymptomatic malaria infections feature an immunosuppressive blood transcriptional signature with upregulation of pathways involved in the control of T‐cell function. These results suggest that asymptomatic malaria is not innocuous and might not support immune processes to fully control parasitemia or efficiently respond to malaria vaccines.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
DOI:
10.15252/msb.202110824
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
2193510-5
SSG:
12
