In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 168, No. 1 ( 2013-01), p. 15-22
Abstract:
To evaluate the effects of short- and long-term treatment with pegvisomant (PEG) on arrhythmias in acromegalic patients resistant to long-term, high-dose therapy with somatostatin analogs (SA). Materials and methods Thirteen patients entered the study. All patients started PEG at initial dose of 10 mg daily and then titrated to 5 mg every 6 weeks on the basis of IGF1. A standard 24-h electrocardiography registration was performed in all patients at baseline and after 6 and 18 months of PEG to evaluate: mean (HR), maximum (MHR), and minimum (mHR) heart rate; pauses number (P) and duration (PD); supraventricular episodes (SEs) number and duration (SED); and ventricular ectopic beats (EB) number and duration (EBD). Left ventricular mass (LVM) was also evaluated by standard echocardiography. Results A slight but not significant decrease in HR, MHR, and mHR was observed after 6-month PEG, whereas a significant decrease in HR ( P =0.03), MHR ( P =0.05), and mHR ( P =0.05) was found after 18-month PEG compared with baseline. LVM significantly ( P =0.05) correlated with MRH ( r =−0.50) after short-term treatment, and with HR ( r =−0.54) and mHR ( r =−0.55) after long-term treatment. Long-term PEG induced the complete recovery of arrhythmias recorded at baseline in one patient and the improvement of rhythm disorders developed after 6-month therapy in another patient. The prevalence of conduction disturbances passed from 15 to 7.7% after long-term PEG. Conclusions Long-term treatment with PEG reduces HR, MHR, and mHR and improves rhythm abnormalities in acromegaly.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2013
detail.hit.zdb_id:
1485160-X
