In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 170, No. 1 ( 2014-01), p. 95-99
Kurzfassung:
Taking levothyroxine ( l -T 4 ) with coffee or with water followed by coffee intake within a few minutes results in poor TSH response in many patients. T 4 is available in tablet form worldwide, but novel formulations in soft gel capsule or liquid form are now available. Design We fortuitously identified a euthyroid patient who wrongly consumed liquid l -T 4 with coffee at breakfast; after changing the time of consumption to 30 min before breakfast, no change in TSH, free T 4 (fT 4 ), and free tri-iodothyronine (fT 3 ) concentrations was observed. Once the first patient was identified, additional stable euthyroid patients who consumed liquid l -T 4 with coffee were identified. Methods Patients were recruited by searching our ‘thyroid patients’ database. All the patients on liquid l -T 4 treatment were contacted by phone to ask them whether they took l -T 4 at breakfast. We identified 54 patients who were submitted to TSH, fT 4 , and fT 3 evaluation, with the indication that the same dosage of l -T 4 be consumed 30 min before breakfast. We determined their TSH, fT 4 , and fT 3 concentrations after 3 and 6 months again. Results No significant difference in thyroid hormone concentrations was observed in patients when they consumed l -T 4 at breakfast or when they consumed it 30 min before breakfast for 3 and 6 months (TSH: 2.5±1.1 vs 2.5±1.1 and 2.4±1.1 mIU/l respectively, fT 4 : 12.4±2.4 vs 12.5±2.4 and 12.3±2.1 pg/ml respectively, and fT 3 : 3.4±0.6 vs 3.4±0.6 and 3.3±0.5 pg/ml respectively). Conclusion Oral liquid l -T 4 formulations could diminish the problem of l -T 4 malabsorption caused by coffee when using traditional tablet formulations.
Materialart:
Online-Ressource
ISSN:
0804-4643
,
1479-683X
Sprache:
Unbekannt
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2014
ZDB Id:
1485160-X
