In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 176, No. 1 ( 2017-01), p. 11-19
Abstract:
Hypomagnesemia (plasma magnesium (Mg 2+ ) concentration 〈 0.7 mmol/L) has been described in patients with type 2 diabetes. Polypharmacy is inevitable when treating a complex disease such as type 2 diabetes and could explain disturbances in the plasma Mg 2+ concentration. In this study, we aimed to establish the extent of hypomagnesemia in a cohort of type 2 diabetes patients and to identify the determinants of plasma Mg 2+ levels. Methods Patient data and samples of 395 type 2 diabetes patients were investigated. Plasma Mg 2+ concentrations were measured using a spectrophotometric assay. Using Pearson correlation analyses, variables were correlated to plasma Mg 2+ levels. After excluding confounding variables, all parameters correlating ( P 〈 0.1) with plasma Mg 2+ were included in a stepwise backward regression model. Results The mean plasma Mg 2+ concentration in this cohort was 0.74 ± 0.10 mmol/L. In total, 121 patients (30.6%) suffered from hypomagnesemia. Both plasma triglyceride ( r = −0.273, P 〈 0.001) and actual glucose levels ( r = −0.231, P 〈 0.001) negatively correlated with the plasma Mg 2+ concentration. Patients using metformin ( n = 251, 62%), proton pump inhibitors ( n = 179, 45%) or β-adrenergic receptor agonists ( n = 31, 8%) displayed reduced plasma Mg 2+ levels. Insulin use ( n = 299, 76%) positively correlated with plasma Mg 2+ levels. The model predicted ( R 2 ) 20% of all variance in the plasma Mg 2+ concentration. Conclusions Hypomagnesemia is highly prevalent in type 2 diabetes patients. Plasma triglycerides and glucose levels are major determinants of the plasma Mg 2+ concentration, whereas only a minor part ( 〈 10%) of hypomagnesemia can be explained by drug intake, excluding polypharmacy as a major cause for hypomagnesemia in type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2017
detail.hit.zdb_id:
1485160-X
