In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 40, No. 2 ( 1962-06), p. 290-296
Abstract:
The effect of endogenous ADH release by nicotine bitartrate on the serum concentrations of protein bound iodine and total iodine was determined by using 131 I as tracer. 15 to 30 minutes after the intravenous injection of 0.01 to 0.06 mg nicotine bitartrate per kg body weight, the thyroid function is not altered ( P 〉 0.05). In previous investigations ( Mertz 1959 a, b ) it was shown that ADH, like vasopressin is capable of stimulating all partial functions of the thyroid if exogenous ADH is given in high doses. It is concluded that (1) the substance stimulating the release of TSH ( i.e. thyrotrophin releasing factor = TRF) is not identical with ADH, (2) that TRF is not released by nicotine and (3) that vasopressin possibly contains ADH and TRF. The action of vasopressin on thyroid function may be due to a similarity in the chemical structures of TRF and ADH ('overlapping phenomenon').
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0400290
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1962
detail.hit.zdb_id:
1485160-X
