In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 70, No. 2 ( 1972-06), p. 315-330
Abstract:
Following a discussion of the potential modification of the neogenesis of corticosterone and cortisol from the endogenous precursor cholesterol in vitro all possible types of modifications have been realized: I. Corticosterone stimulation; II. Cortisol stimulation; III. Total stimulation; IV. Total inhibition; V. Cortisol inhibition; VI. Corticosterone inhibition. Most of the substances involved belong to the class of 3- and 4-mono-substituted pyridine derivatives. Of particular interest are the corticosterone blockers of type VI which lead to a concomitant stimulation of cortisol formation. The effects of one of these corticosterone blockers on various labelled precursors suggest the existence of two different 21-hydroxylases, one for 17α-deoxy- and another for 17α-hydroxy-C21-steroids. A possible mechanism of action of these compounds and the pathological equivalents of the resulting enzyme deficiencies are discussed.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0700315
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1972
detail.hit.zdb_id:
1485160-X
