In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 155, No. suppl_1 ( 2006-11), p. S107-S114
Kurzfassung:
Objective : Sex hormones are not only involved in the formation of reproductive organs, but also induce sexually-dimorphic brain development and organization. Cross-sex hormone administration to transsexuals provides a unique possibility to study the effects of sex steroids on brain morphology in young adulthood. Methods : Magnetic resonance brain images were made prior to, and during, cross-sex hormone treatment to study the influence of anti-androgen + estrogen treatment on brain morphology in eight young adult male-to-female transsexual human subjects and of androgen treatment in six female-to-male transsexuals. Results : Compared with controls, anti-androgen + estrogen treatment decreased brain volumes of male-to-female subjects towards female proportions, while androgen treatment in female-to-male subjects increased total brain and hypothalamus volumes towards male proportions. Conclusions : The findings suggest that, throughout life, gonadal hormones remain essential for maintaining aspects of sex-specific differences in the human brain.
Materialart:
Online-Ressource
ISSN:
0804-4643
,
1479-683X
Sprache:
Unbekannt
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2006
ZDB Id:
1485160-X
