In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 156, No. 3 ( 2007-03), p. 377-385
Abstract:
Objective : Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the development of several components of metabolic syndrome (MetS). The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors. Subjects and methods : The population-based study sample comprised 1630 subjects aged 55–74 years from KORA S4 (Cooperative Health Research in the Region of Augsburg Survey 4). Genotyping was carried out by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis of allele-dependent primer extension products. Results : The MCP-1 SNP c.-3813C 〉 T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid ( P = 0.0084, 0.014, 0.027). Other trends were observed for c.-928G 〉 C associated with height and fasting glucose ( P = 0.0024, 0.033), for c.105T 〉 C with height and leukocytes ( P = 0.0095, 0.047), for c.*65C 〉 T and c.*3879C 〉 T with MCP-1 levels (both P = 0.012) and for c.-2138A 〉 T with interleukin-6 levels. After correction for multiple testing, none of the analysed SNPs, except c.-928G 〉 C in men showed a significant association with MetS, T2DM or other analysed parameters. Haplotype MCP-1*1 and c.-928G 〉 C in men ( P = 0.0002, 0.0004) were significantly associated with an increase in height. Conclusions : This is the first study to investigate the associations of MCP-1 SNPs with MetS. We found trends for several components of MetS. These parameters were hyperlipidaemia, fasting and 2-h glucose, and uric acid. A new finding is that MCP-1*1 haplotype is associated with height. Further investigation in larger populations is needed to clarify the involvement of MCP-1 in MetS.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2007
detail.hit.zdb_id:
1485160-X
