In:
Genetics, Oxford University Press (OUP), Vol. 172, No. 4 ( 2006-04-01), p. 2689-2694
Abstract:
In yeast, the nonhomologous end joining pathway (NHEJ) mobilizes the DNA polymerase Pol4 to repair DNA double-strand breaks when gap filling is required prior to ligation. Using telomere–telomere fusions caused by loss of the telomeric protein Rap1 and double-strand break repair on transformed DNA as assays for NHEJ between fully uncohesive ends, we show that Pol4 is able to extend a 3′-end whose last bases are mismatched, i.e., mispaired or unpaired, to the template strand.
Type of Medium:
Online Resource
ISSN:
1943-2631
DOI:
10.1534/genetics.105.053512
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2006
detail.hit.zdb_id:
1477228-0
SSG:
12
