In:
Acta Veterinaria Hungarica, Akademiai Kiado Zrt., Vol. 69, No. 1 ( 2021-06-05), p. 73-79
Abstract:
The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)–pyometra complex. Group 1 ( n = 10) included bitches with open cervix pyometra, while Group 2 ( n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 ( P 〈 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands ( r = 0.926; P 〈 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 ( r = −0.652; P 〈 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH–pyometra complex as well as in the endometrium of healthy bitches in dioestrus.
Type of Medium:
Online Resource
ISSN:
0236-6290
,
1588-2705
DOI:
10.1556/004.2021.00013
Language:
Unknown
Publisher:
Akademiai Kiado Zrt.
Publication Date:
2021
detail.hit.zdb_id:
2110474-8
SSG:
22
