In:
Acta Cirurgica Brasileira, FapUNIFESP (SciELO), Vol. 21, No. suppl 3 ( 2006), p. 76-88
Abstract:
INTRODUCTION: The babassu mesocarp (Orbignya phalerata) has been used in experimental research studies focused on its antiinflammatory action. In state of Maranhão - Brazil it is widely used not only as food, but also as popular medicine in wound healing process. PURPOSE: To evaluate the action of Orbignya phalerata extract in macroscopic, histologicic and tensiometric aspects in the healing process of median laparotomy in rats. METHODS: Forty male adult Wistar rats were submitted to an incision in the alba linea, sutured back in one plan with separated stitches of polypropilene 5-0. After regular procedure, the animals were divided into two groups of 20 rats each. To the group named control an intraperitoneal, dose of 1,0 ml of saline solution per kilogram of body weight was done. To the experimental group, the same thing was also done, but instead of saline solution it was injected water solution of babassu, in a dose of 50 mg/kg. The animals were observed in the following days. All of them were killed within a three and seven day post-operative period schedule, and then a histological and tensiometric analysis was carried out. RESULTS: On macroscopic examination no relevant adherence, between the alba linea and the abdominal organs in the study groups, was found. Histological evaluation presented marginal significant effects (p=0,86) to acute inflammation and significant effects (p=0,003) to giant cell reaction in both control and experimental three days groups. Significant difference was observed to acute inflammation in both seven days control and experimental groups. In the intragroup analysis (control three and seven) some marginal significant effect was in relationship to acute and chronic inflammation. In the interexperimental groups analysis, only the giant cell reactions (0,002) and colagenization had significant results. The tensiometric evaluation showed in the seven day experimental group more resistence then others. CONCLUSION: The macroscopic and histological evaluation didn't show any significant difference between the experimental and control groups, but the tensiometric evaluation at the 7th day experimental group had significant difference compared to the control group, signalizing that the use of the extract of babassu intraperitoneally injected can improve the healing process.
Type of Medium:
Online Resource
ISSN:
0102-8650
DOI:
10.1590/S0102-86502006000900011
Language:
Unknown
Publisher:
FapUNIFESP (SciELO)
Publication Date:
2006
detail.hit.zdb_id:
2012156-8
