In:
Biomolecules and Biomedicine, Association of Basic Medical Sciences of FBIH, ( 2023-05-14)
Abstract:
Quantification of measurable residual disease (MRD) correlates with the risk of leukaemia recurrence in adults with B-cell acute lymphoblastic leukaemia (ALL). However, it remains unknown whether collecting data on cysteine and glycine-rich protein 2 (CSRP2) transcript levels, after completing the second course of consolidation, improves prognosis prediction accuracy. A total of 204 subjects with B-cell ALL were tested for CSPR2 transcripts after completing the second course of consolidation using quantitative real-time polymerase chain reaction (qRT-PCR) and divided into high (N = 32) and low (N = 172) CSRP2 expression cohorts. In multivariable analyses, subjects with high expression of CSRP2 had a higher 5-year cumulative incidence of relapse (CIR) (Hazard Ratio [HR] = 2. 57 [1.38, 4.76] ; P = 0.003), lower 5-year relapse-free survival (RFS) (HR = 3.22 [1.75, 5.93]; P 〈 0.001) and overall survival (OS) (HR = 4.59 [2.64, 7.99]; P 〈 0.001) in the whole cohort, as well as in the multiparametric flow cytometry (MPFC) measurable residual disease (MRD)- negative cohort (for CIR, HR = 2.70 [1.19, 6.12]; for RFS, HR = 4.37 [1.94, 9.85] ; for OS, HR = 4.90 [2.43, 9.90]; P 〈 0.05). Prognostic analysis showed that allogeneic hematopoietic stem cell transplantation (allo-HSCT) could significantly improve the prognosis of patients with high CSRP2 transcript levels (allo-HSCT vs chemotherapy: 5-year CIR, 52% vs 91%; RFS, 41% vs 9%; OS, 38% vs 20%; P 〈 0.05). Our data indicates that incorporating data from CSPR2 transcript levels to the MRD-testing at the end of the second course of consolidation therapy enhances prognosis prediction accuracy in adults with B-cell ALL.
Type of Medium:
Online Resource
ISSN:
2831-090X
,
2831-0896
DOI:
10.17305/bb.2023.9034
Language:
Unknown
Publisher:
Association of Basic Medical Sciences of FBIH
Publication Date:
2023
detail.hit.zdb_id:
3149181-9
