In:
Complex Issues of Cardiovascular Diseases, NII KPSSZ, Vol. 7, No. 4S ( 2019-02-03), p. 36-46
Abstract:
Aim . To evaluate the safety of the pulmonary artery radiofrequency catheter denervation in different pulmonary hypertension (PH) clinical forms. Methods . 6 patients with different clinical forms of PH were included in the study with the further randomization into two groups. Group I patient (n = 3) underwent pulmonary denervation and group II patients (n = 3) underwent a placebo procedure. The examination of patients included routine clinical tests, the measurements of N-terminal precursor of the brain natriuretic peptide (NT-proBNP) levels, coagulation blood tests, ECG recordings, echocardiography (with the estimation of mean pulmonary artery pressure), chest X-ray, the assessment of the respiratory function, right heart catheterization (RHC), six-minute walk test (6MWT), the assessment of the quality of life according to the SF-36 questionnaire. Intraoperative measures indicating the safety of the procedure were also studied. Results . There were no statistically significant differences found in the intraoperative data between the groups. None intraoperative and postoperative complications during in the in-hospital period found. Mean pulmonary artery pressure reduced in two patients without any elevations 24 hours following the intervention. A decrease in mean pulmonary arterial pressure from 48 to 41 mm Hg was observed in a patient with primary PH. The second patient with post-embolic pulmonary hypertension demonstrated a reduction in mean pulmonary artery pressure from 43 to 32 mm Hg. The third patient had no changes according to the RHC. All three patients showed a positive tendency according to the 6MWT and echocardiography, while none of these changes were recorded in Group II. The mean NT-pro-BNP level in Group I decreased from 1767±291 to 488±129 vs. 1519±305 and 1594±337 in Group II, respectively (P = 0.013). Conclusion Pulmonary artery denervation is a safe and promising treatment method, but further studies are required to prove its effectiveness.
Type of Medium:
Online Resource
ISSN:
2587-9537
,
2306-1278
DOI:
10.17802/2306-1278-2018-7-4S
DOI:
10.17802/2306-1278-2018-7-4S-36-46
Language:
Unknown
Publisher:
NII KPSSZ
Publication Date:
2019
