In:
Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 13, No. 6 ( 2023-02-23), p. 55-62
Abstract:
BACKGROUND: Information about the features of intact bone tissue of the contralateral segment in the treatment of tuberculous osteitis is absent in the literature. AIM: Study of the features of intact bone tissue in the conditions of complex treatment of experimental tuberculous osteitis. MATERIALS AND METHODS: On an experimental model of tuberculous osteitis of the condyle of the right femur (Mycobacterium tuberculosis H37Rv) in 21 rabbits, the morphometric characteristics of the contralateral femurs, representatively selected from 4 groups, were studied: group (control) who did not receive either surgical or medical treatment; groups 24 radical surgical removal of the focus, supplemented: No. 2 antituberculosis therapy, group 3 antituberculosis therapy and a single injection of bisphosphonates (pamidronate), group 4 a single injection of bisphosphonates. In autopsy material studied: the area of bone tissue, the thickness of bone beams, the number of osteoblasts, osteocytes, osteoclasts and the proportion of their active forms. RESULTS: The following features were revealed in intact samples of different groups: group 1 the minimum area of bone tissue and the thickness of the beams, the maximum number of osteoblasts, including active ones, the average number of osteocytes; groups 2 and 3 average values of the area and thickness of bone beams, the average number of osteoblasts, the pool of osteocytes is represented mainly by inactive cells; groups 3 and 4 the minimum value of active osteoblasts; group 4 the maximum thickness of the bone beams, a greater total number of osteoblasts and osteocytes. No osteoclasts were found in any group. CONCLUSIONS: Different ratios of bone tissue area, thickness of bone beams, and osteoforming cellular elements in animals receiving different treatment indicate both the systemic effect of a specific process and the drug effect of anti-tuberculosis drugs and bisphosphonates on uninfected bones.
Type of Medium:
Online Resource
ISSN:
2587-6252
,
2079-7850
DOI:
10.17816/PED13655-62
Language:
Unknown
Publisher:
ECO-Vector LLC
Publication Date:
2023
