In:
Acta Biochimica Polonica, Polskie Towarzystwo Biochemiczne (Polish Biochemical Society), Vol. 52, No. 4 ( 2005-11-21), p. 927-930
Abstract:
In this study the contribution of the ERK1/2 pathway to sphingosine-induced death and morphological changes of the actin cytoskeleton in glioma C6 cells was investigated. Surprisingly, the level of ERK1/2 phosphorylation does not change after incubation of cells with sphingosine. Despite this, sphingosine induces rounding and detachment of cells without formation of apoptotic bodies. To shed light on this process, a specific inhibitor of ERK1/2 phosphorylation, U0126, was used. Cells incubated simultaneously with sphingosine and U0126 not only detached, but also exhibited formation of apoptotic-like blebs. These data suggest that during sphingosine-induced glioma C6 cell death apoptotic blebbing is dependent on ERK1/2 signalling and occurs only when ERK1/2 activity is decreased or abolished.
Type of Medium:
Online Resource
ISSN:
1734-154X
,
0001-527X
DOI:
10.18388/abp.2005_3409
Language:
Unknown
Publisher:
Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)
Publication Date:
2005
detail.hit.zdb_id:
2086022-5
