In:
Journal of Periodontology, Wiley, Vol. 85, No. 10 ( 2014-10), p. 1424-1431
Kurzfassung:
Background: Crohn disease (CD) is a chronic inflammatory bowel disease often accompanied by periodontal symptoms. Based on its function in immune response, tumor necrosis factor (TNF)‐α and its genetic variants have been discussed as risk indicators in inflammatory processes. Therefore, the aim of the present study is to investigate the impact of TNF‐α polymorphisms on periodontal parameters and inflammatory lesions of oral mucosa as a characteristic of CD. Methods: A total of 142 patients with CD were included in the study. Oral soft tissue alterations and periodontal parameters were assessed. Genotypes, alleles, and haplotypes of TNF‐α polymorphisms (rs1800629, cDNA−308G 〉 A; and rs361525, cDNA−238G 〉 A) were determined by polymerase chain reaction with sequence‐specific primers (PCR‐SSP). Results: Patients with CD who exhibit more severe oral soft tissue alterations were significantly more often A allele carriers of rs361525 than G allele carriers (14.2% versus 2.2%; P 〈 0.001). Furthermore, A allele carriers had a higher mean periodontal probing depth ( P 〈 0.05), mean clinical attachment level ( P 〈 0.05), and sites with bleeding on probing (not significant). Similar results were obtained when evaluating A allele‐containing genotypes (AG + AA) and haplotypes (GA). In multivariate analyses considering age, sex, smoking, and medication as confounders, the A allele was proven to be an independent risk indicator for oral soft tissue alterations in patients with CD. No genotype‐dependent influence of rs1800629 was observed. Conclusion: The TNF‐α A allele of rs361525 represents a significant risk indicator for oral soft tissue alterations in patients with CD.
Materialart:
Online-Ressource
ISSN:
0022-3492
,
1943-3670
DOI:
10.1902/jop.2014.130644
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2040047-0
