In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 28, No. 11 ( 2021-04), p. 2114-2136
Abstract:
The costs of developing, validating and buying new drugs are dramatically increasing.
On the other hand, sobering economies have difficulties in sustaining their healthcare systems, particularly in countries with an elderly population requiring increasing welfare. This
conundrum requires immediate action, and a possible option is to study the large, already present arsenal of drugs approved and to use them for innovative therapies. This possibility is
particularly interesting in oncology, where the complexity of the cancer genome dictates in most patients a multistep therapeutic approach. In this review, we discuss a) Computational
approaches; b) preclinical models; c) currently ongoing or already published clinical trials in the drug repurposing field in oncology; and d) drug repurposing to overcome resistance to
previous therapies.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867327999200817104912
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3