In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 28, No. 23 ( 2021-08-02), p. 4742-4798
Kurzfassung:
Gold-based complexes represent a new class of potential
metallodrugs. Although their action mechanism is not entirely understood, it was shown that gold complexes inhibit some enzymes’ activities. Among them, Na,K-ATPase is
emerging as an essential target for various anticancer drugs. The functionalization of nanoparticles by gold(III) complexes could facilitate their delivery into the cells and enable
the following of their distribution in the target tissues. Objective: The paper presents an overview of Na,K-ATPase interaction with representative
and structurally related cytotoxic gold(III) complexes. The results obtained by the employment of theoretical methods (DFT and docking studies) combined with the experimental
approach involving a variety of nanotechnology-base techniques (UV/Vis, Raman and fluorescence spectroscopy, CD, AFM, DLS) are discussed. Detailed information was
obtained on the enzyme’s conformational and structural changes upon binding the gold(III) complexes. The experimentally determined reaction parameters (constants of
dissociation and the reaction stoichiometry) were predicted theoretically. Conclusion: The presented results offer further support to the view that Na,K-ATPase
may be a relevant biomolecular target for cytotoxic gold(III) compounds of medicinal interest.
Materialart:
Online-Ressource
ISSN:
0929-8673
DOI:
10.2174/0929867328999210101233801
Sprache:
Englisch
Verlag:
Bentham Science Publishers Ltd.
Publikationsdatum:
2021
SSG:
15,3
