In:
Current Molecular Medicine, Bentham Science Publishers Ltd., Vol. 21, No. 8 ( 2021-10), p. 698-705
Abstract:
Inclusion of anticancer drugs into biocompatible
nanoparticulate carriers decreases the general toxicity and improves the efficacy of clinical treatments due to the reduction of soluble circulating free drugs. Methods: In addition, removal of emerging drug contaminants from wastewaters is a
necessity that should be seriously attended. Boron nitride (BN) is a choice in drug delivery because of its many surprising properties. Here, boron nitride nanoparticles are
prepared, characterized by Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD) and used in the delivery of melphalan anti-cancer drug. Results: Then, density functional theory (DFT) calculations are carried out to study the
adsorption of this drug on the surface of pure boron nitride fullerene via familiar hybrid functionals B3LYP and B3PW91. In addition, the polarizable continuum model (PCM)
calculations show that BN is stable in water. Conclusion: Finally, the in vitro cellular toxicity and viability of BN nanoparticles was
examined on ES-2 cancer cells. The inhibitory dose IC50 of the material confirmed acceptable cytotoxicity and nanoparticles affected the average growth of the ES-2
cancer cells.
Type of Medium:
Online Resource
ISSN:
1566-5240
DOI:
10.2174/1566524021666210111104428
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
