In:
Current Neurovascular Research, Bentham Science Publishers Ltd., Vol. 20, No. 1 ( 2023-02), p. 132-139
Abstract:
To characterize the macula microvasculature using fractal dimension (FD) in
hypertensive white matter hyperintensity (WMH) participants and explore the association between the microvascular changes and serum uric acid levels. Methods: Thirty-eight WMH participants were dementia and stroke-free, and 37 healthy controls
were enrolled. Optical coherence tomographic angiography (OCTA) was used to image the superficial vascular complex (SVC), deep vascular complex (DVC), and inner vascular complex (IVC) in a
2.5-mm diameter concentric circle (excluding the foveal avascular zone FAZ). A commercial algorithm was used to quantify the complexity and density of the three capillary layers by fractal analysis. Results: WMH participants showed significantly lower FD value in the SVC (P = 0.002), DVC (P 〈 0.001) and IVC (P = 0.012) macula microvasculature compared with control group. After adjusting
for risk factors (hypertension, diabetes, age and gender) SVC (P = 0.035) and IVC (P = 0.030) significantly correlated with serum uric acid. Conclusions: Serum uric acid levels are associated with microvascular changes in WMH. Fractal
dimension based on OCTA imaging could help quantitatively characterize the macula microvasculature changes in WMH and may be a potential screening tool to detect serum uric acid level changes.
Type of Medium:
Online Resource
ISSN:
1567-2026
DOI:
10.2174/1567202620666221027095220
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
