In:
Current Topics in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 2 ( 2022-01), p. 132-149
Abstract:
Bergenin, 4-O-methyl gallic acid glucoside, is a bioactive compound in various plants
belonging to different families. The present work compiles scattered information on pharmacology, structure-activity relationship and nanotechnological aspects of bergenin, collected from various
electronic databases such as Sci Finder, PubMed, Google Scholar, etc. Bergenin has been reported to exhibit hepatoprotective, anti-inflammatory, anticancer, neuroprotective, antiviral, and antimicrobial
activities. Molecular docking studies have shown that isocoumarin pharmacophore of bergenin is essential for its bioactivities. Bergenin holds a great potential to be used as a lead molecule and
also as a therapeutic agent for the development of more efficacious and safer semisynthetic derivatives. Nanotechnological concepts can be employed to overcome the poor bioavailability of bergenin.
Finally, it is concluded that bergenin can emerge as clinically potential medicine in modern therapeutics.
Type of Medium:
Online Resource
ISSN:
1568-0266
DOI:
10.2174/1568026621666211015092654
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3