In:
Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 5 ( 2023-04), p. 692-701
Abstract:
Quercetin is a kind of flavonoid with important bioactivities, such as
hypoglycemic, antioxidant, anti-inflammatory, and anti-allergic properties. Although it is unstable, it is worth exploring how to better exert its anti-allergic effect. Objective: The current study aimed to elucidate the anti-allergic effect of quercetin liposomes on
RBL-2H3 cells in vitro. Methods: Quercetin liposomes were prepared to improve the anti-allergic activity of quercetin
through a green thin-film dispersion method. We compared the anti-allergic effects of quercetin and quercetin liposomes in RBL-2H3 cells. The anti-allergic activity of the quercetin liposomes
was evaluated by the level of β-hexosaminidase, histamine, Ca2+, IL-4, IL-8, and MCP-1. Results: The results showed that quercetin liposomes could significantly restrain the release of
β-hexosaminidase and histamine, calcium influx, and the expression of inflammatory factors, whose effect is stronger than quercetin. Conclusion: Collectively, our research suggests that the quercetin liposome can be used as a
potential allergy antagonist.
Type of Medium:
Online Resource
ISSN:
1871-5303
DOI:
10.2174/1871530322666220627151830
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
