In:
Current Traditional Medicine, Bentham Science Publishers Ltd., Vol. 7, No. 3 ( 2021-09-07), p. 440-446
Abstract:
To evaluate the effects of “XGTQ” in the treatment of cirrhosis induced by
Carbon tetrachloride (CCL4) in combination with alcohol and a high-fat diet on Wistar rats. Materials and methods: Cirrhosis on white rats was induced by subcutaneously injecting CC14 at
an initial dose of 5,0ml/kg, followed by 1,2ml/kg once a week in 10 weeks. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered every day
with plain water and 1 day with water mixed with 30% ethanol. The rats were randomly divided into 5 groups and given distilled water (group 1 and 2 or control group), silymarin (group 3 or reference
group) or the “XGTQ” drug extract (group 4, 5) for 4 weeks. Collected blood for biochemical test and liver were dissected to evaluate weight, morphology, and quantified 4-hydroxyproline to
evaluate fibrosis and collagen accumulation. Results: n cirrhotic Wistar rats, “XGTQ” drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability
toreduce the activity of enzymes AST, ALT in the blood (p 〈 0.01), increasing plasma albumin
and decreasing prothrombin time (p 〈 0.05); improving physical condition, macroscopic and microscopic
images of H & E-stained liver; decreasing the concentration of hydroxyproline in the liver and
reducing the level of cirrhosis on the Masson-stained templates. The effects of “XGTQ” increased with the dose and was equivalent to silymarin at the dose of 70 mg/kg/24h. Conclusion: The extract of “XGTQ” drug is effective in treating cirrhosis in Wistar rats.
Type of Medium:
Online Resource
ISSN:
2215-0838
DOI:
10.2174/2215083806999201113120427
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
