In:
Biomarkers in Medicine, Future Medicine Ltd, Vol. 13, No. 11 ( 2019-08-01), p. 931-940
Abstract:
Aim: The aim of the study was to explore the effects of variants at HMGCR-KIF6loci on a range of cardio-metabolic phenotypes. Methods: We analyzed the range of variants within Genetics in Brisighella Health Study and KIF6 genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu. Results: We defined directly the effects of rs3846662:C 〉 A at HMGCR on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in KIF6 gene did not reveal any associations with cardiometabolic phenotypes. Conclusion: This study highlights effect of HMGCR locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.
Type of Medium:
Online Resource
ISSN:
1752-0363
,
1752-0371
DOI:
10.2217/bmm-2017-0431
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2019