In:
Biomarkers in Medicine, Future Medicine Ltd, Vol. 10, No. 1 ( 2016-01), p. 73-79
Abstract:
Aim: LG72 can increase mitochondrial ROSs and oxidative stress has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The serum level of LG72 or LG72-related molecules might therefore be associated with ALS. Here, we aim to determine the serum autoantibody against LG72 has potential as a biomarker for the diagnosis of ALS. Materials: Seventy-eighty patients with ALS, 45 patients with AD, 43 patients with PD and 88 healthy adults were enrolled. Results: The concentration of serum autoantibody against LG72 was more than fourfold lower in ALS than other control groups (p 〈 0.001). The AUC was 0.9627 when the cut-off value for autoantibody concentration was 0.167 μg/ml. Conclusion: This finding suggests that the autoantibody against LG72 might serve as a surrogate biomarker for ALS.
Type of Medium:
Online Resource
ISSN:
1752-0363
,
1752-0371
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2016