In:
Epigenomics, Future Medicine Ltd, Vol. 13, No. 21 ( 2021-11), p. 1735-1746
Abstract:
Aim: We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. Data sources: PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January 2000 to 30 June 2019. Study appraisal & synthesis methods: Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included race/ethnicity data. Results: 16 studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from more than 95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. Conclusion: In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.
Type of Medium:
Online Resource
ISSN:
1750-1911
,
1750-192X
DOI:
10.2217/epi-2020-0007
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2021
SSG:
12