In:
Epigenomics, Future Medicine Ltd, Vol. 14, No. 19 ( 2022-10), p. 1197-1212
Abstract:
Plain language summary Genes are divided into coding genes and noncoding genes, and people have always focused on coding genes because coding genes guide the synthesis of proteins and proteins are the main bearers of life activities. However, the fact that such important coding genes occupy only 2% of the large human genome shows that noncoding genes are far more complex and important than we think. Through scientific exploration, it has been found that noncoding genes are an important part of gene expression regulation. The end products of noncoding genes, such as miRNAs, also have their own expression patterns at different stages of the body's development, and an imbalance in expression patterns often causes various diseases. There are multiple levels of gene expression regulation during noncoding RNAs biogenesis, and this paper fully reviews the role and the mechanisms of gene expression regulation in miRNA biogenesis. Familiarity with gene expression regulation in miRNA biogenesis is important to understand the mechanisms of dysregulation of miRNA expression profiles in diseases and the treatments employed.
Type of Medium:
Online Resource
ISSN:
1750-1911
,
1750-192X
DOI:
10.2217/epi-2022-0214
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2022
SSG:
12
