In:
Nanomedicine, Future Medicine Ltd, Vol. 13, No. 21 ( 2018-11), p. 2777-2789
Abstract:
Aim: The β-CD-LPC molecule was synthesized based on the conjugation of LPC and β-CD molecules and it could self-assemble into liposome which was used to encapsulate the Dox to form nanomedicine for the cancer therapy. Materials & methods: The anticancer and antitumor effect of β-CD-LPC-Dox nanomedicine was studied with the vitro and vivo experimental methods. Results: The result showed that β-CD-LPC liposome had high Dox drug-loading rate and a good sustained-release effect. Cell experiment showed that the β-CD-LPC-Dox nanomedicine could effectively induce cancer cell apoptosis and in vivo experiments showed that β-CD-LPC-Dox liposome could effectively inhibit tumor growth and had an effective anticancer activity with lower biotoxicity. Conclusion: The β-CD-LPC-Dox nanomedicine could be applied as a candidate drug to therapy the cancer.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2018-0172
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2018
SSG:
15,3