In:
Nanomedicine, Future Medicine Ltd, Vol. 17, No. 20 ( 2022-08), p. 1449-1461
Kurzfassung:
Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol (celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials & methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents epithelial–mesenchymal transition in lens epithelial cells induced by TGF-β1 through the TGF-β1/Smad2/3/TEAD1 signaling pathway. In vivo efficiency evaluations showed that CMG demonstrated an excellent inhibitory effect on PCO in rabbits and had no obvious tissue toxicity. Conclusion: Injectable CMG may represent a promising ophthalmic platform for preventing PCO. This versatile injectable micelle–hydrogel hybrid represents a clinically relevant platform to achieve localized therapy and controlled release of drugs in other disease therapies.
Materialart:
Online-Ressource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2022-0191
Sprache:
Englisch
Verlag:
Future Medicine Ltd
Publikationsdatum:
2022
SSG:
15,3
