In:
Personalized Medicine, Future Medicine Ltd, Vol. 13, No. 3 ( 2016-05), p. 233-240
Abstract:
Aim: To identify potential genetic risk markers associated with 5-fluorouracil (5-FU) treatment outcomes in plantar warts patients. Methods: In this study, 126 plantar warts patients were treated with an intralesional mixture of 5-FU, lidocaine and epinephrine. Treatment outcomes were compared with DNA mutation analysis. Results: More patients with TSER 3R/3R genotype failed 5-FU treatment than TSER 2R/3R+2R/2R (72.1 vs 43.8%; odds ratio: 3.32; 95% CI: 1.26–8.72; p = 0.013). In addition, the regression modeling identified patient age and TSER 3R allele as covariates of the risk of 5-FU treatment failure (p = 0.025). Conclusion: TSER 3R/3R of TYMS gene was found to be the major risk of treatment failure. This genetic marker provides a potential treatment stratification target to modulate 5-FU treatment in plantar wart patients.
Type of Medium:
Online Resource
ISSN:
1741-0541
,
1744-828X
DOI:
10.2217/pme-2015-0014
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2016
SSG:
15,3