In:
Arhiv za bioloske nauke, National Library of Serbia, Vol. 67, No. 4 ( 2015), p. 1339-1347
Abstract:
Given its possible protective effect on vascular endothelial function, we
hypothesized that the circulating level of insulin-like growth factor 1
(IGF-1) could be associated with biomarkers of endothelial dysfunction and
vascular inflammation, i.e., soluble intercellular adhesion molecule 1
(sICAM-1), soluble E-selectin (sE-selectin) and high-sensitivity C-reactive
protein (hs-CRP, in non-diabetic obese women. A total of 40 obese women
(median age 35 (31-39) years; moderately obese I (n=21) body mass index (BMI)
30.0-34.9 kg/m2 and severely obese (n=19) BMI 35.0-39.9 kg/m2) and 40
controls, age-matched healthy nonobese women were included in the study.
Anthropometric parameters (BMI, waist circumference, fat adipose tissue
percentage ? FAT% measured by bioelectrical impedance analysis), serum
concentrations of biomarkers (IGF-1, sICAM-1, sE-selectin and hs-CRP) and
common carotid artery intima-media thickness Z-score (CCIMT Z-score) were
assessed in all subjects. Severely obese subjects had a significantly lower
median concentration of IGF-1 compared to moderately obese and nonobese
subjects (95 (73.75-109.25) vs. 120 (108.3-141.7) vs. 115.5 (94.1-165.5)
mg/mL, P〈0.05). In moderately obese subjects, the median concentration of
hs-CRP (3.41 (2.3-5.1) vs. 5.9 (3.2-9.57) mg/L, P=0.01) and sICAM-1 (244.5
(192.7-262.2) vs. 325.2 (229.2-339.6) mg/L, P=0.03) were significantly lower
compared to severely obese subjects. In regression analysis IGF-1
concentration was independently associated with FAT% (?=-3.14; P=0.03),
hs-CRP (?=-4.24; P=0.001) and CCIMT Z-score (?=-19.2; P=0.001). The
circulating level of IGF-1 is associated with hs-CRP, but not with
sE-selectin and sICAM-1 in non-diabetic obese women.
Type of Medium:
Online Resource
ISSN:
0354-4664
,
1821-4339
DOI:
10.2298/ABS150430111I
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2015
detail.hit.zdb_id:
2380842-1
