In:
Medical review, National Library of Serbia, Vol. 75, No. 1-2 ( 2022), p. 5-11
Kurzfassung:
Introduction. Modification of tryptophan metabolism during the progression of
chronic kidney disease may have significant pathophysiological consequences.
The aim of this study was to investigate the status of metabolic products of
tryptophan, indoxyl sulfate and kynurenine in different stages of chronic
kidney disease. Material and Methods. In all participants included in the
cross-sectional study (n = 66) with previously diagnosed chronic kidney
disease, the parameters of renal function were measured: glomerular
filtration rate using radionuclide plasma clearance with 99mTc-labelled
diethylene triamine penta-acetate and effective renal plasma flow using
131Ilabeled orthoiodohippuric acid. Plasma concentrations of indoxyl sulfate
and kynurenine were measured by high-performance liquid chromatography.
Results. A significant difference was observed in the concentrations of both
metabolites between the observed groups (Group II - measured glomerular
filtration rate - 15 - 60 ml/min/1.73 m?; n = 36 vs. Group I measured
glomerular filtration rate 〉 60 l/ min/1.73 m?; n = 26): indoxyl sulfate
1.07 ? 0.89 vs. 2.44 ? 4.05 ?g/ ml, p 〈 0.001; kynurenine 3.15 ? 0.22 vs.
3.21 ? 0.17 ?g/ml, p 〈 0.05. The correlation was statistically significant
between glomerular filtration rate and kynurenine - r = -0.38, p = 0.001 and
indoxyl sulfate - r = 0.56, p ? 0.001; effective plasma renal flow and
kynurenine - r = -0.33, p 〈 0.05 and indoxyl sulfate - r = 0.46, p ? 0.001.
Conclusion. There is a significant difference in the plasma concentrations
of indoxyl sulfate and kynurenine in the group of patients with glomerular
filtration rate of 15 - 60 ml/min/1.73 m? compared to patients with
glomerular filtration rate 〉 60 ml/min/1.73 m?. In patients with chronic
kidney disease, plasma concentrations of both metabolites of tryptophan are
inversely correlated with the glomerular filtration rate and effective
plasma renal flow.
Materialart:
Online-Ressource
ISSN:
0025-8105
,
1820-7383
DOI:
10.2298/MPNS2202005I
Sprache:
Englisch
Verlag:
National Library of Serbia
Publikationsdatum:
2022
ZDB Id:
2381028-2
